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KMID : 1100220150140010012
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Dementia and Neurocognitive Disorders
2015 Volume.14 No. 1 p.12 ~ p.16
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Risk Factors for Post-Lumbar Puncture Headache in a Study of Alzheimer’s Disease Biomarkers
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Park So-Young
Wang Min-Jeong
Jang Jae-Hoon
Park Young-Ho
Lee Joon-Woo
Kim Sang-Yun
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Abstract
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Background and Purpose : In memory clinics, the lumbar puncture (LP) is increasingly being used to evaluate cerebrospinal fluid for biomarkers of Alzheimer’s disease (AD). Post-lumbar puncture headache (PLPH) is the most frequent complication of LP, and can prove to be a barrier for the performance of LP.
Methods : We retrospectively collected data from 59 subjects (patients with AD and cognitively healthy controls) who were enrolled in a study aimed to identify AD biomarkers via LP. In order to determine whether subjects experienced PLPH, we assessed recorded follow-up telephone interviews. To analyze the association between the occurrence of PLPH and several demographic- and procedure-related factors, a multiple logistic regression analysis with backward stepwise method was performed.
Results : The overall frequency of PLPH was 49.15%. PLPH was more frequent in younger subjects and clinical diagnosis was associated with PLPH. The use of cutting-edge needles was also suggested as a statistically significant factor in the development of PLPH, and was determined to be the only factor that could be modified in order to lower the frequency of PLPH.
Conclusions : Age, clinical diagnosis, and needle type were all determined to be predictive factors of PLPH.
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KEYWORD
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post-lumbar puncture headache, Alzheimer’s disease, risk factor.
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